GMP Standard Female Hormone Steroids Hemisuccinate Meprednisone

High quality Meprednisone

Item: Meprednisone
Meprednisone CAS No.: 1247-42-3
Meprednisone Purity: 99% min
Meprednisone Standard: USP
Meprednisone MF: C22H28O5
Meprednisone MOQ: 10grams
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Meprednisone

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Betapar (Meprednisone) is a glucocorticoid and a methylated derivative of prednisone. The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to altered interconversion between these steroids. An improved pharmacokinetic/dynamic receptor/gene-mediated model characterized the steroid receptor binding and induction of tyrosine aminotransferase activity after i.v. MPL sodium succinate (10 mg/kg). In contrast to previous in vitro studies, ketoconazole at maximally tolerated doses failed to antagonize the steroid receptor-mediated activity of MPL.

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